About: Regulated Intramembrane Proteolysis     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Regulated Intramembrane Proteolysis
rdfs:subClassOf
Semantic_Type
  • Phenomenon or Process
Preferred_Name
  • Regulated Intramembrane Proteolysis
UMLS_CUI
  • C2987018
FULL_SYN
  • Regulated Intramembrane ProteolysisPTNCI
  • Intramembrane ProteolysisSYNCI
  • RIPSYNCI
DEFINITION
  • A process that involves the proteolysis of an integral membrane protein at a site that is within its transmembrane domain. This cleavage causes the release of cytosolic fragments that can enter the nucleus and regulate transcription.NCI
DesignNote
  • Regulated intramembrane proteolysis of a transmembrane protein usually follows the proteolytic shedding of the extracellular domain. Regulated intramembrane proteolysis is involved in many biological processes including embryonic development, cholesterol signaling and Alzheimer disease.
code
  • C95245
is someValuesFrom of
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