About: DNA Methyltransferase Inhibitor SGI-110     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • DNA Methyltransferase Inhibitor SGI-110
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
  • Nucleic Acid, Nucleoside, or Nucleotide
Preferred_Name
  • DNA Methyltransferase Inhibitor SGI-110
NCI_META_CUI
  • CL426698
PDQ_Open_Trial_Search_ID
  • 691684
PDQ_Closed_Trial_Search_ID
  • 691684
FULL_SYN
  • S110CNNCI
  • DNA Methyltransferase Inhibitor SGI-110PTNCI
  • SGI-110CNNCI
  • DNMT inhibitor SGI-110ABNCI
DEFINITION
  • A dinucleotide antimetabolite of a decitabine linked via phosphodiester bond to a guanosine, with potential antineoplastic activity. Following metabolic activation by phosphorylation and incorporation into DNA, SGI-110 inhibits DNA methyltransferase, thereby causing genome-wide and non-specific hypomethylation, and inducing cell cycle arrest at S-phase. This agent is resistant to cytidine deaminase, hence may result in gradual release of decitabine both extra and intracellularly, leading to more prolonged exposures to decitabine.NCI
code
  • C95209
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