About: BCR/ABL1 Fusion Gene     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • BCR/ABL1 Fusion Gene
rdfs:subClassOf
Semantic_Type
  • Gene or Genome
Preferred_Name
  • BCR/ABL1 Fusion Gene
UMLS_CUI
  • C1835417
ALT_DEFINITION
  • A gene formed when pieces of chromosomes 9 and 22 break off and trade places. The ABL gene from chromosome 9 joins to the BCR gene on chromosome 22, to form the BCR-ABL fusion gene. The changed chromosome 22 with the fusion gene on it is called the Philadelphia chromosome. The BCR-ABL fusion gene is found in most patients with chronic myelogenous leukemia (CML), and in some patients with acute lymphoblastic leukemia (ALL) or acute myelogenous leukemia (AML).NCI-GLOSS
FULL_SYN
  • BCR-ABL fusion geneSYNCI-GLOSSCDR0000561237
  • BCR/ABL1 Fusion GeneSYNCITCGA
  • BCR-ABL OncogeneSYNCI
  • BCR-ABLSYNCI
  • BCR-ABL Fusion GeneSYNCI
  • BCR-ABL1 Fusion GeneSYNCI
  • BCR/ABL1 Fusion GenePTNCI
DEFINITION
  • A fusion gene that results from a translocation t(9;22)(q34;q11) that fuses the 5' part of the BCR gene to the 5' side of exon 2 of the ABL1 gene. There are 3 potential products that are formed depending on which BCR exon has the breakpoint. All of the protein products have constitutively active tyrosine kinase activity. This fusion is associated with both chronic myeloid leukemia and acute lymphoblastic leukemia.NCI
code
  • C94600
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is someValuesFrom of
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