About: Recombinant Human Fusion Protein L19TNFalpha     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Recombinant Human Fusion Protein L19TNFalpha
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Pharmacologic Substance
Preferred_Name
  • Recombinant Human Fusion Protein L19TNFalpha
NCI_META_CUI
  • CL426023
PDQ_Open_Trial_Search_ID
  • 686947
PDQ_Closed_Trial_Search_ID
  • 686947
FULL_SYN
  • Recombinant Human Fusion Protein L19TNFalphaPTNCI
  • L19-TNF-alphaABNCI
DEFINITION
  • An immunocytokine consisting of human pro-inflammatory cytokine tumor necrosis factor alpha (TNFalpha) fused to a human single-chain variable fragment (scFv) directed against the extra-domain B (ED-B) of fibronectin (L19), with potential immunopotentiating and antineoplastic activities. The L19 moiety of recombinant human fusion protein L19TNFalpha binds to the ED-B domain of fibronectin on tumor cells in the tumor neovasculature. In turn, the TNFalpha moiety may locally induce an immune response against ED-B fibronectin-expressing tumor cells and may specifically decrease the proliferation of ED-B-expressing tumor cells. ED-B is predominantly expressed during angiogenesis and tumor growth.NCI
code
  • C94210
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