About: Ad-REIC/DKK3 Vaccine     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Ad-REIC/DKK3 Vaccine
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
  • Virus
Preferred_Name
  • Ad-REIC/DKK3 Vaccine
NCI_META_CUI
  • CL426018
PDQ_Open_Trial_Search_ID
  • 685820
PDQ_Closed_Trial_Search_ID
  • 685820
FULL_SYN
  • Ad-REIC/dickkopf homolog 3SYNCI
  • Ad-REIC/DKK3 VaccinePTNCI
DEFINITION
  • A replication incompetent adenoviral vector encoding the full-length tumor suppressor gene Reduced Expression in Immortalized Cells (REIC or DKK3) (ad-REIC/DKK3), with potential antineoplastic activity. Upon intratumoral injection, tumor cells express REIC/DKK3 protein. This may result in the activation of c-Jun-NH2-kinase (JNK) and ultimately apoptosis via Bcl2 suppression and caspase-3 activation. Expression of REIC/DKK3 is normal in healthy cells but reduced or absent in many cancer cells; Forced overexpression of REIC/DKK3 in cancer cells may lead to an induction of tumor cell apoptosis and reduction of tumor cell growth while sparing normal, healthy cells naturally expressing endogenous REIC/DKK3.NCI
code
  • C94205
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