About: Pappalysin-1     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Pappalysin-1
rdfs:subClassOf
equivalentClass
Has_NICHD_Parent
Concept_In_Subset
OMIM_Number
  • 176385
Semantic_Type
  • Amino Acid, Peptide, or Protein
Preferred_Name
  • Pappalysin-1
UMLS_CUI
  • C2984583
Contributing_Source
  • NICHD
FULL_SYN
  • EC 3.4.24.79SYNCI
  • Pappalysin-1PTNCI
  • Pregnancy-Associated Plasma Protein ASYNCI
  • PAPP-ASYNCI
  • Pregnancy Associated Plasma Protein APTNICHD
  • Insulin-Like Growth Factor-Dependent IGF-Binding Protein 4 ProteaseSYNCI
  • IGF-Dependent IGFBP-4 ProteaseSYNCI
  • IGFBP-4aseSYNCI
Swiss_Prot
  • Q13219
DEFINITION
  • NCIPappalysin-1 (1627 aa, ~181 kDa) is encoded by the human PAPPA gene. This protein is involved in the modulation of proteolysis.
DesignNote
  • Low plasma levels of pappalysin-1 during pregnancy may be a biomarker of an aneuploid fetus.
  • Pappalysin-1 specifically cleaves IGFBP-4 between 143-Ser and Lys-144 and IGFBP-5 between 135-Met and Lys-136. (UniProt)
code
  • C91825
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