About: Amoebiasis Pathway

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Attributes	Values
rdf:type	Class
rdfs:label	Amoebiasis Pathway
rdfs:subClassOf	Infectious Disease Pathway
Semantic_Type	Functional Concept
Preferred_Name	Amoebiasis Pathway
UMLS_CUI	C2984573
KEGG_ID	hsa05146
ALT_DEFINITION	Entamoeba histolytica, an extracellular protozoan parasite, is a human pathogen that invades the intestinal epithelium. Infection occurs upon ingestion of contaminated water and food. The pathogenesis of amoebiasis begins with parasite attachment and disruption of the intestinal mucus layer, followed by apoptosis of host epithelial cells. Intestinal tissue destruction causes severe dysentery and ulcerations in amoebic colitis. Several amoebic proteins such as lectins, cysteine proteinases, and amoebapores are associated with the invasion process. The parasite can cause extraintestinal infection, like amoebic liver abscess, by evading the immune response.KEGG
FULL_SYN	AmoebiasisPTKEGG Amoebiasis PathwayPTNCI Entamoeba histolytica Infection PathwaySYNCI E. histolytica Infection PathwaySYNCI
code	C91808
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