About: Pegylated Arginine Deiminase     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Pegylated Arginine Deiminase
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Pegylated Arginine Deiminase
UMLS_CUI
  • C1328192
ALT_DEFINITION
  • A substance being studied in the treatment of melanoma, liver cancer, and other types of cancer. It breaks down the amino acid arginine and may block the growth of cancer cells that need arginine to grow. It is a type of iminohydrolase.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 355725
PDQ_Closed_Trial_Search_ID
  • 355725
FULL_SYN
  • Pegylated Arginine DeiminasePTNCI
  • pegylated arginine deiminasePTNCI-GLOSSCDR0000543120
  • ADI-PEG 20PTNCI-GLOSSCDR0000562556
DEFINITION
  • An agent consisting of the arginine-degrading enzyme arginine deiminase combined with polyethylene glycol (20,000 MW) (ADI-PEG 20) with potential antineoplastic activity. Upon administration, arginine deiminase breaks down the amino acid arginine into citrulline. Although arginine is a nonessential amino acid for normal human cells, certain cancer cells are autotrophic for arginine and need arginine in order to survive. Depletion of arginine may lead to an inhibition of cellular proliferation in those cancer cells. ADI is coupled to PEG in order to enhance this agent's half-life.NCI
code
  • C91702
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