About: Chagas Disease Pathway

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Attributes	Values
rdf:type	Class
rdfs:label	Chagas Disease Pathway
rdfs:subClassOf	Infectious Disease Pathway
Semantic_Type	Functional Concept
Preferred_Name	Chagas Disease Pathway
UMLS_CUI	C2984330
KEGG_ID	hsa05142
ALT_DEFINITION	Trypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they invade diverse host cells including cardiomyocytes. Establishment of infection depends on various parasite molecules such as cruzipain, oligopeptidase B, and trans-sialidase that activate Ca2+ signaling. Internalized parasites escape from the parasitophorous vacuole using secreted pore-forming TcTOX molecule and replicate in the cytosol. Multiplied parasites eventually lyse infected host cells and are released in the circulation. During these events, the parasites manipulate host innate immunity and elicit cardiomyocyte hypertrophy. T lymphocyte responses are also disturbed.KEGG
FULL_SYN	Chagas disease (American trypanosomiasis)PTKEGG Chagas Disease PathwayPTNCI Trypanosoma cruzi Infection PathwaySYNCI T. cruzi Infection PathwaySYNCI Chagas diseaseSYKEGG
code	C91525
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