About: TGF-beta Signaling Pathway KEGG

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About: TGF-beta Signaling Pathway KEGG Goto Sponge NotDistinct Permalink

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Attributes	Values
rdf:type	Class
rdfs:label	TGF-beta Signaling Pathway KEGG
rdfs:subClassOf	Signaling Pathway
Semantic_Type	Functional Concept
Preferred_Name	TGF-beta Signaling Pathway KEGG
UMLS_CUI	C2984328
KEGG_ID	hsa04350
ALT_DEFINITION	The transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species ranging from worms and insects to mammals. A wide spectrum of cellular functions such as proliferation, apoptosis, differentiation and migration are regulated by TGF-beta family members. TGF-beta family member binds to the Type II receptor and recruits Type I, whereby Type II receptor phosphorylates and activates Type I. The Type I receptor, in turn, phosphorylates receptor-activated Smads (R-Smads: Smad1, Smad2, Smad3, Smad5, and Smad8). Once phosphorylated, R-Smads associate with the co-mediator Smad, Smad4, and the heteromeric complex then translocates into the nucleus. In the nucleus, Smad complexes activate specific genes through cooperative interactions with other DNA-binding and coactivator (or co-repressor) proteins.KEGG
FULL_SYN	TGF-beta signaling pathwayPTKEGG TGF-beta Signaling Pathway KEGGPTNCI
code	C91522
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