About: Jak-STAT Signaling Pathway

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Attributes	Values
rdf:type	Class
rdfs:label	Jak-STAT Signaling Pathway
rdfs:subClassOf	Signaling Pathway
Semantic_Type	Functional Concept
Preferred_Name	Jak-STAT Signaling Pathway
UMLS_CUI	C2984327
KEGG_ID	hsa04630
ALT_DEFINITION	The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors.KEGG
FULL_SYN	Jak-STAT Signaling PathwayPTNCI Jak-STAT signaling pathwayPTKEGG
code	C91519
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