About: ERBB Family Signaling Pathway

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: ERBB Family Signaling Pathway Goto Sponge NotDistinct Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	ERBB Family Signaling Pathway
rdfs:subClassOf	Signaling Pathway
Semantic_Type	Functional Concept
Preferred_Name	ERBB Family Signaling Pathway
UMLS_CUI	C2984323
KEGG_ID	hsa04012
ALT_DEFINITION	The ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including proliferation, differentiation, cell motility, and survival. Ligand binding to the four closely related members of this RTK family-epidermal growth factor receptor (EGFR, also known as ErbB-1 or HER1), ErbB-2 (HER2), ErbB-3 (HER3), and ErbB-4 (HER4)-induces the formation of receptor homo- and heterodimers and the activation of the intrinsic kinase domain, resulting in phosphorylation on specific tyrosine residues (pY) within the cytoplasmic tail. Signaling effectors containing binding pockets for pY-containing peptides are recruited to activated receptors and induce the various signaling pathways. The Shc- and/or Grb2-activated mitogen-activated protein kinase (MAPK) pathway is a common target downstream of all ErbB receptors. Similarly, the phosphatidylinositol-3-kinase (PI-3K) pathway is directly or indirectly activated by most ErbBs. Several cytoplasmic docking proteins appear to be recruited by specific ErbB receptors and less exploited by others. These include the adaptors Crk, Nck, the phospholipase C gamma (PLCgamma), the intracellular tyrosine kinase Src, or the Cbl E3 ubiquitin protein ligase.KEGG
FULL_SYN	ErbB signaling pathwayPTKEGG ERBB Family Signaling PathwayPTNCI
code	C91514
is someValuesFrom of	nodeID://b641479 nodeID://b641613 nodeID://b641639 nodeID://b641663 nodeID://b641671 nodeID://b642316 nodeID://b642424 nodeID://b642464 nodeID://b643010 nodeID://b647980 nodeID://b648051 nodeID://b648436 nodeID://b649110 nodeID://b652329 nodeID://b652672 nodeID://b654887 nodeID://b654919 nodeID://b654953 nodeID://b654988 nodeID://b656454 nodeID://b667776 nodeID://b668564 nodeID://b668726 nodeID://b668796 nodeID://b668840 nodeID://b669209 nodeID://b669234 nodeID://b670468 nodeID://b671332 nodeID://b672309 nodeID://b672828 nodeID://b674241 nodeID://b688125 nodeID://b688303 nodeID://b688441 nodeID://b688493 nodeID://b688568 nodeID://b688654 nodeID://b688727 nodeID://b688902 nodeID://b689065 nodeID://b689160 nodeID://b689285 nodeID://b689337 nodeID://b691396 nodeID://b693255 nodeID://b698684 nodeID://b698715 nodeID://b699419 nodeID://b699529 nodeID://b699863 nodeID://b699915 nodeID://b700704 nodeID://b700771 nodeID://b701170 nodeID://b702781 nodeID://b702894 nodeID://b703076 nodeID://b705073 nodeID://b705114 nodeID://b705177 nodeID://b705252 nodeID://b706009 nodeID://b707266 nodeID://b709344 nodeID://b710901 nodeID://b711218 nodeID://b711244 nodeID://b712523 nodeID://b712547 nodeID://b712602 nodeID://b724385 nodeID://b725667 nodeID://b726242 nodeID://b726272 nodeID://b726502

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 18 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software