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AttributesValues
rdf:type
rdfs:label
  • RNA Degradation Pathway
rdfs:subClassOf
Semantic_Type
  • Functional Concept
Preferred_Name
  • RNA Degradation Pathway
UMLS_CUI
  • C2984321
KEGG_ID
  • hsa03018
ALT_DEFINITION
  • The correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay exist and both pathways are initiated by poly(A) shortening of the mRNA. In the 5' to 3' pathway, this is followed by decapping which then permits the 5' to 3' exonucleolytic degradation of transcripts. In the 3' to 5' pathway, the exosome, a large multisubunit complex, plays a key role. The exosome exists in archaeal cells, too. In bacteria, endoribonuclease E, a key enzyme involved in RNA decay and processing, organizes a protein complex called degradosome. RNase E or R interacts with the phosphate-dependent exoribonuclease polynucleotide phosphorylase, DEAD-box helicases, and additional factors in the RNA-degrading complex.KEGG
FULL_SYN
  • RNA Degradation PathwayPTNCI
  • RNA degradationPTKEGG
code
  • C91512
is someValuesFrom of
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