About: Peroxisome Biogenesis Pathway     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Peroxisome Biogenesis Pathway
rdfs:subClassOf
Semantic_Type
  • Functional Concept
Preferred_Name
  • Peroxisome Biogenesis Pathway
UMLS_CUI
  • C2984308
KEGG_ID
  • hsa04146
ALT_DEFINITION
  • Peroxisomes are essential organelles that play a key role in redox signaling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ether lipids and free radical detoxification. The biogenesis of peroxisomes starts with the early peroxins PEX3, PEX16 and PEX19 and proceeds via several steps. The import of membrane proteins into peroxisomes needs PEX19 for recognition, targeting and insertion via docking at PEX3. Matrix proteins in the cytosol are recognized by peroxisomal targeting signals (PTS) and transported to the docking complex at the peroxisomal membrane. Peroxisomes' deficiencies lead to severe and often fatal inherited peroxisomal disorders (PD). PDs are usually classified in two groups. The first group is disorders of peroxisome biogenesis which include Zellweger syndrome, and the second group is single peroxisomal enzyme deficiencies.KEGG
FULL_SYN
  • PeroxisomePTKEGG
  • Peroxisome Biogenesis PathwayPTNCI
code
  • C91498
is someValuesFrom of
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