About: Papillary Thyroid Carcinoma Pathway

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About: Papillary Thyroid Carcinoma Pathway Goto Sponge NotDistinct Permalink

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Attributes	Values
rdf:type	Class
rdfs:label	Papillary Thyroid Carcinoma Pathway
rdfs:subClassOf	Cancer Pathway
Semantic_Type	Functional Concept
Preferred_Name	Papillary Thyroid Carcinoma Pathway
UMLS_CUI	C2984307
KEGG_ID	hsa05216
ALT_DEFINITION	Papillary thyroid carcinoma (PTC), the most frequent neoplasia originating from the thyroid epithelium, accounts for about 80% of all thyroid cancers. Chimeric oncogenes, created by chromosomal rearrangements involving prevalently RET and, to a less extent, NTRK1 loci, are implicated in the development of papillary carcinoma. These are inappropriately expressed and stimulate constitutive signaling, bypassing the need for receptor activation by growth factors. Alternatively, mutant RAS directly stimulates BRAF, whereas mutant BRAF directly stimulates MEK.KEGG
FULL_SYN	Thyroid Cancer PathwaySYNCI PTC PathwaySYNCI Papillary Thyroid Carcinoma PathwayPTNCI Thyroid cancerPTKEGG
code	C91496
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