About: p53 Signaling Pathway KEGG

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Attributes	Values
rdf:type	Class
rdfs:label	p53 Signaling Pathway KEGG
rdfs:subClassOf	Signaling Pathway Cell Cycle Regulation Pathway
Semantic_Type	Functional Concept
Preferred_Name	p53 Signaling Pathway KEGG
UMLS_CUI	C2984306
KEGG_ID	hsa04115
ALT_DEFINITION	p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.KEGG
FULL_SYN	p53 signaling pathwayPTKEGG p53 Signaling Pathway KEGGPTNCI
code	C91495
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