About: Progesterone-Mediated Oocyte Maturation Pathway

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Attributes	Values
rdf:type	Class
rdfs:label	Progesterone-Mediated Oocyte Maturation Pathway
rdfs:subClassOf	Cell Differentiation or Development Pathway
Semantic_Type	Functional Concept
Preferred_Name	Progesterone-Mediated Oocyte Maturation Pathway
UMLS_CUI	C2984303
KEGG_ID	hsa04914
ALT_DEFINITION	Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division cycles and maturation of the oocyte into a mature, fertilizable egg. This process is termed oocyte maturation. The transition is accompanied by an increase in maturation promoting factor (MPF or Cdc2/cyclin B) which precedes germinal vesicle breakdown (GVBD). Most reports point towards the Mos-MEK1-ERK2 pathway [where ERK is an extracellular signal-related protein kinase, MEK is a MAPK/ERK kinase and Mos is a p42(MAPK) activator] and the polo-like kinase/CDC25 pathway as responsible for the activation of MPF in meiosis, most likely triggered by a decrease in cAMP.KEGG
FULL_SYN	Progesterone-Mediated Oocyte Maturation PathwayPTNCI Progesterone-mediated oocyte maturationPTKEGG
code	C91492
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