About: Long-Term Potentiation Pathway

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About: Long-Term Potentiation Pathway Goto Sponge NotDistinct Permalink

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Attributes	Values
rdf:type	Class
rdfs:label	Long-Term Potentiation Pathway
rdfs:subClassOf	Homeostasis Regulation Pathway
Semantic_Type	Functional Concept
Preferred_Name	Long-Term Potentiation Pathway
UMLS_CUI	C2984294
KEGG_ID	hsa04720
ALT_DEFINITION	Hippocampal long-term potentiation (LTP), a long-lasting increase in synaptic efficacy, is the molecular basis for learning and memory. Tetanic stimulation of afferents in the CA1 region of the hippocampus induces glutamate release and activation of glutamate receptors in dendritic spines. A large increase in [Ca2+]i resulting from influx through NMDA receptors leads to constitutive activation of CaM kinase II (CaM KII) . Constitutively active CaM kinase II phosphorylates AMPA receptors, resulting in potentiation of the ionic conductance of AMPA receptors. Early-phase LTP (E-LTP) expression is due, in part, to this phosphorylation of the AMPA receptor. It is hypothesized that postsynaptic Ca2+ increases generated through NMDA receptors activate several signal transduction pathways including the Erk/MAP kinase and cAMP regulatory pathways. The convergence of these pathways at the level of the CREB/CRE transcriptional pathway may increase expression of a family of genes required for late-phase LTP (L-LTP).KEGG
FULL_SYN	LTP PathwayABNCI Long-term potentiationPTKEGG Long-Term Potentiation PathwayPTNCI
code	C91482
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