About: Gap Junction Assembly Pathway

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Attributes	Values
rdf:type	Class
rdfs:label	Gap Junction Assembly Pathway
rdfs:subClassOf	Regulatory Pathway
Semantic_Type	Functional Concept
Preferred_Name	Gap Junction Assembly Pathway
UMLS_CUI	C2984290
KEGG_ID	hsa04540
ALT_DEFINITION	Gap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels', each containing six connexins, contributed by each neighboring cell. These channels permit the direct transfer of small molecules including ions, amino acids, nucleotides, second messengers and other metabolites between adjacent cells. Gap junctional communication is essential for many physiological events, including embryonic development, electrical coupling, metabolic transport, apoptosis, and tissue homeostasis. Communication through Gap Junction is sensitive to a variety of stimuli, including changes in the level of intracellular Ca2+, pH, transjunctional applied voltage and phosphorylation/dephosphorylation processes. This figure represents the possible activation routes of different protein kinases involved in Cx43 and Cx36 phosphorylation.KEGG
FULL_SYN	Gap junctionPTKEGG Gap Junction Assembly PathwayPTNCI
code	C91478
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