About: Fc Epsilon Receptor I Signaling Pathway KEGG

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Attributes	Values
rdf:type	Class
rdfs:label	Fc Epsilon Receptor I Signaling Pathway KEGG
rdfs:subClassOf	Immune Response Regulation Pathway
Semantic_Type	Functional Concept
Preferred_Name	Fc Epsilon Receptor I Signaling Pathway KEGG
UMLS_CUI	C2984288
KEGG_ID	hsa04664
ALT_DEFINITION	Fc epsilon RI-mediated signaling pathways in mast cells are initiated by the interaction of antigen (Ag) with IgE bound to the extracellular domain of the alpha chain of Fc epsilon RI. The activation pathways are regulated both positively and negatively by the interactions of numerous signaling molecules. Mast cells that are thus activated release preformed granules which contain biogenic amines (especially histamines) and proteoglycans (especially heparin). The activation of phospholipase A2 causes the release of membrane lipids followed by development of lipid mediators such as leukotrienes (LTC4, LTD4 and LTE4) and prostaglandins (especially PDG2). There is also secretion of cytokines, the most important of which are TNF-alpha, IL-4 and IL-5. These mediators and cytokines contribute to inflammatory responses.KEGG
FULL_SYN	Fc Epsilon Receptor I Signaling Pathway KEGGPTNCI Fc epsilon RI signaling pathwayPTKEGG
code	C91476
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