About: Pathogenic Escherichia coli Infection Pathway

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Attributes	Values
rdf:type	Class
rdfs:label	Pathogenic Escherichia coli Infection Pathway
rdfs:subClassOf	Infectious Disease Pathway
Semantic_Type	Functional Concept
Preferred_Name	Pathogenic Escherichia coli Infection Pathway
UMLS_CUI	C2984286
KEGG_ID	hsa05130
ALT_DEFINITION	Enteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC) are closely related pathogenic strains of Escherichia coli. The hallmark of EPEC/EHEC infections is induction of attaching and effacing (A/E) lesions that damage intestinal epithelial cells. The capacity to form A/E lesions is encoded mainly by the locus of enterocyte effacement (LEE) pathogenicity island. Tir, Map, EspF, EspG are known LEE-encoded effector proteins secreted via the type III secretion system, which is also LEE-encoded, into the host cell. EPEC and EHEC Tir's link the extracellular bacterium to the cell cytoskeleton. Map and EspF are involved in mitochondrion membrane permeabilization. EspG interacts with tubulins and stimulates microtubule destabilization. LEE-encoded adhesin or intimin (Eae) is exported via the general secretory pathway to the periplasm, where it is inserted into the outer membrane. In addition to Tir, two potential host cell-carried intimin receptors, beta1 integrin (ITGB1) and nucleolin (NCL), have so far been identified. The distinguishing feature of EHEC is the elaboration of Shiga-like toxin (Stx). Stx cleaves ribosomal RNA, thereby disrupting protein synthesis and killing the intoxicated epithelial or endothelial cells.KEGG
FULL_SYN	Pathogenic Escherichia coli Infection PathwayPTNCI Pathogenic E. coli Infection PathwaySYNCI Pathogenic Escherichia coli infectionPTKEGG
code	C91474
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