About: Chronic Myeloid Leukemia Pathway     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Chronic Myeloid Leukemia Pathway
rdfs:subClassOf
Semantic_Type
  • Functional Concept
Preferred_Name
  • Chronic Myeloid Leukemia Pathway
UMLS_CUI
  • C2984277
KEGG_ID
  • hsa05220
ALT_DEFINITION
  • Chronic myelogenous leukaemia (CML) is a biphasic disease, initiated by expression of the BCR/ABL fusion gene product in self-renewing, haematopoietic stem cells (HSCs). HSCs can differentiate into common myeloid progenitors (CMPs), which then differentiate into granulocyte/macrophage progenitors (GMPs). HSCs can also differentiate into common lymphoid progenitors (CLPs), which are the progenitors of lymphocytes such as T cells and B cells. The initial chronic phase of CML (CML-CP) is characterized by a massive expansion of the granulocytic-cell series. Acquisition of additional genetic mutations beyond expression of BCR/ABL causes the progression of CML from chronic phase to blast phase (CML-BP), characterized by an accumulation of myeloid or lymphoid blast cells.KEGG
FULL_SYN
  • Chronic Myeloid Leukemia PathwayPTNCI
  • CML PathwayABNCI
  • Chronic myeloid leukemiaPTKEGG
code
  • C91465
is someValuesFrom of
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