About: Long-Term Depression Pathway

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Attributes	Values
rdf:type	Class
rdfs:label	Long-Term Depression Pathway
rdfs:subClassOf	Homeostasis Regulation Pathway
Semantic_Type	Functional Concept
Preferred_Name	Long-Term Depression Pathway
UMLS_CUI	C2984275
KEGG_ID	hsa04730
ALT_DEFINITION	Cerebellar long-term depression (LTD), thought to be a molecular and cellular basis for cerebellar learning, is a process involving a decrease in the synaptic strength between parallel fiber (PF) and Purkinje cells (PCs) induced by the conjunctive activation of PFs and climbing fiber (CF). Multiple signal transduction pathways have been shown to be involved in this process. Activation of PFs terminating on spines in dendritic branchlets leads to glutamate release and activation of both AMPA and mGluRs. Activation of CFs, which make multiple synaptic contacts on proximal dendrites, also via AMPA receptors, opens voltage-gated calcium channels (VGCCs) and causes a generalized influx of calcium. These cellular signals, generated from two different synaptic origins, trigger a cascade of events culminating in a phosphorylation-dependent, long-term reduction in AMPA receptor sensitivity at the PF-PC synapse. This may take place either through receptor internalization and/or through receptor desensitization.KEGG
FULL_SYN	Long-Term Depression PathwayPTNCI Long-term depressionPTKEGG
code	C91463
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