About: Hematopoietic Cell Lineage Pathway

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About: Hematopoietic Cell Lineage Pathway Goto Sponge NotDistinct Permalink

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Attributes	Values
rdf:type	Class
rdfs:label	Hematopoietic Cell Lineage Pathway
rdfs:subClassOf	Immune Response Regulation Pathway
Semantic_Type	Functional Concept
Preferred_Name	Hematopoietic Cell Lineage Pathway
UMLS_CUI	C2984271
KEGG_ID	hsa04640
ALT_DEFINITION	Blood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid progenitor (CLP) or a common myeloid progenitor (CMP). A CLP gives rise to the lymphoid lineage of white blood cells or leukocytes-the natural killer (NK) cells and the T and B lymphocytes. A CMP gives rise to the myeloid lineage, which comprises the rest of the leukocytes, the erythrocytes (red blood cells), and the megakaryocytes that produce platelets important in blood clotting. Cells undergoing this differentiation process express a stage- and lineage-specific set of surface markers. Therefore cellular stages are identified by the specific expression patterns of these genes.KEGG
FULL_SYN	Hematopoietic Cell Lineage PathwayPTNCI Hematopoietic cell lineagePTKEGG
code	C91459
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