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AttributesValues
rdf:type
rdfs:label
  • Base Excision Repair Pathway
rdfs:subClassOf
Semantic_Type
  • Functional Concept
Preferred_Name
  • Base Excision Repair Pathway
UMLS_CUI
  • C2984269
KEGG_ID
  • hsa03410
ALT_DEFINITION
  • Base excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair initiated by lesion-specific DNA glycosylases and completed by either of the two sub-pathways: short-patch BER where only one nucleotide is replaced and long-patch BER where 2-13 nucleotides are replaced. Each sub-pathway of BER relies on the formation of protein complexes that assemble at the site of the DNA lesion and facilitate repair in a coordinated fashion. This process of complex formation appears to provide an increase in specificity and efficiency to the BER pathway, thereby facilitating the maintenance of genome integrity by preventing the accumulation of highly toxic repair intermediates.KEGG
FULL_SYN
  • Base Excision Repair PathwayPTNCI
  • Base excision repairPTKEGG
code
  • C91457
is someValuesFrom of
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