About: B Cell Receptor Signaling Pathway

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Attributes	Values
rdf:type	Class
rdfs:label	B Cell Receptor Signaling Pathway
rdfs:subClassOf	Immune Response Regulation Pathway
Semantic_Type	Functional Concept
Preferred_Name	B Cell Receptor Signaling Pathway
NCI_META_CUI	CL422162
KEGG_ID	hsa04662
ALT_DEFINITION	B cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor (BCR) is an integral membrane protein complex that is composed of two immunoglobulin (Ig) heavy chains, two Ig light chains and two heterodimers of Ig-alpha and Ig-beta. After BCR ligation by antigen, three main protein tyrosine kinases (PTKs) -the SRC-family kinase LYN, SYK and the TEC-family kinase BTK- are activated. Phosphatidylinositol 3-kinase (PI3K) and phospholipase C-gamma 2 (PLC-gamma 2) are important downstream effectors of BCR signalling. This signalling ultimately results in the expression of immediate early genes that further activate the expression of other genes involved in B cell proliferation, differentiation and Ig production as well as other processes.KEGG
FULL_SYN	B Cell Receptor Signaling PathwayPTNCI B cell receptor signaling pathwayPTKEGG BCR Signaling PathwayABNCI
code	C91456
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