About: Allograft Rejection Pathway     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Allograft Rejection Pathway
rdfs:subClassOf
Semantic_Type
  • Functional Concept
Preferred_Name
  • Allograft Rejection Pathway
UMLS_CUI
  • C2984265
KEGG_ID
  • hsa05330
ALT_DEFINITION
  • After transplantation of organ allografts, there are two pathways of antigen presentation. In the direct pathway, recipient T cells react to intact allogeneic MHC molecules expressed on the surface of donor cells. This pathway would activate host CD4 or CD8 T cells. In contrast, donor MHC molecules (and all other proteins) shed from the graft can be taken up by host APCs and presented to recipient T cells in the context of self-MHC molecules - the indirect pathway. Such presentation activates predominantly CD4 T cells. A direct cytotoxic T-cell attack on graft cells can be made only by T cells that recognize the graft MHC molecules directly. Nontheless, T cells with indirect allospecificity can contribute to graft rejection by activating macrophages, which cause tissue injury and fibrosis, and are also likely to be important in the development of an alloantibody response to graft.KEGG
FULL_SYN
  • Allograft Rejection PathwayPTNCI
  • Allograft rejectionPTKEGG
code
  • C91452
is someValuesFrom of
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