About: T Cell Receptor Signaling Pathway KEGG

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About: T Cell Receptor Signaling Pathway KEGG Goto Sponge NotDistinct Permalink

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Attributes	Values
rdf:type	Class
rdfs:label	T Cell Receptor Signaling Pathway KEGG
rdfs:subClassOf	Immune Response Regulation Pathway
Semantic_Type	Functional Concept
Preferred_Name	T Cell Receptor Signaling Pathway KEGG
UMLS_CUI	C2984263
KEGG_ID	hsa04660
ALT_DEFINITION	Activation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. Engagement of these receptors through the interaction with a foreign antigen associated with major histocompatibility complex molecules and CD28 counter-receptors B7.1/B7.2, respectively, results in a series of signaling cascades. These cascades comprise an array of protein-tyrosine kinases, phosphatases, GTP-binding proteins and adaptor proteins that regulate generic and specialised functions, leading to T-cell proliferation, cytokine production and differentiation into effector cells.KEGG
FULL_SYN	T cell receptor signaling pathwayPTKEGG T Cell Receptor Signaling Pathway KEGGPTNCI TCR Signaling PathwaySYNCI
code	C91450
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