About: Nucleotide Excision Repair Pathway

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Attributes	Values
rdf:type	Class
rdfs:label	Nucleotide Excision Repair Pathway
rdfs:subClassOf	DNA Repair Pathway
Semantic_Type	Functional Concept
Preferred_Name	Nucleotide Excision Repair Pathway
UMLS_CUI	C2984260
KEGG_ID	hsa03420
ALT_DEFINITION	Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar.KEGG
FULL_SYN	Nucleotide Excision Repair PathwayPTNCI Nucleotide excision repairPTKEGG
code	C91447
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