About: Pancreatic Cancer Pathway

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Pancreatic Cancer Pathway Goto Sponge NotDistinct Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Pancreatic Cancer Pathway
rdfs:subClassOf	Cancer Pathway
Semantic_Type	Functional Concept
Preferred_Name	Pancreatic Cancer Pathway
UMLS_CUI	C2984259
KEGG_ID	hsa05212
ALT_DEFINITION	Normal duct epithelium progresses to infiltrating cancer through a series of histologically defined precursors (PanINs). The overexpression of HER-2/neu and activating point mutations in the K-ras gene occur early, inactivation of the p16 gene at an intermediate stage, and the inactivation of p53, SMAD4, and BRCA2 occur relatively late. Activated K-ras engages multiple effector pathways. Although EGF receptors are conventionally regarded as upstream activators of RAS proteins, they can also act as RAS signal transducers via RAS-induced autocrine activation of the EGFR family ligands. Pancreatic ductal adenocarcinoma (PDA) show elevated expression of EGF receptors (e.g. HER2/neu) and their ligands (e.g. TGF-alpha) consistent with the presence of this autocrine loop. Moreover, PDA shows extensive genomic instability and aneuploidy. Telomere attrition and mutations in p53 and BRCA2 are likely to contribute to these phenotypes. Inactivation of the SMAD4 tumour suppressor gene leads to loss of the inhibitory influence of the transforming growth factor-beta signaling pathway.KEGG
FULL_SYN	Pancreatic Cancer PathwayPTNCI Pancreatic cancerPTKEGG
code	C91446
is someValuesFrom of	nodeID://b641488 nodeID://b642370 nodeID://b642438 nodeID://b642479 nodeID://b643019 nodeID://b647994 nodeID://b648070 nodeID://b648455 nodeID://b649124 nodeID://b652603 nodeID://b653971 nodeID://b654811 nodeID://b658014 nodeID://b662089 nodeID://b668083 nodeID://b668101 nodeID://b668116 nodeID://b668140 nodeID://b668588 nodeID://b668999 nodeID://b669217 nodeID://b669242 nodeID://b670492 nodeID://b681316 nodeID://b682684 nodeID://b684497 nodeID://b684828 nodeID://b685797 nodeID://b687949 nodeID://b688135 nodeID://b688355 nodeID://b688468 nodeID://b688503 nodeID://b688611 nodeID://b688696 nodeID://b688912 nodeID://b689106 nodeID://b689211 nodeID://b689313 nodeID://b689347 nodeID://b693296 nodeID://b695063 nodeID://b695270 nodeID://b699480 nodeID://b699542 nodeID://b702842 nodeID://b702907 nodeID://b705087 nodeID://b705129 nodeID://b706062 nodeID://b706163 nodeID://b706203 nodeID://b706398 nodeID://b706626 nodeID://b706727 nodeID://b706820 nodeID://b707433 nodeID://b707525 nodeID://b707571 nodeID://b710388 nodeID://b711147 nodeID://b711190 nodeID://b712439 nodeID://b712489 nodeID://b720320 nodeID://b720337

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 18 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software