About: Lysosome Assembly Pathway

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Attributes	Values
rdf:type	Class
rdfs:label	Lysosome Assembly Pathway
rdfs:subClassOf	Degradation Pathway
Semantic_Type	Functional Concept
Preferred_Name	Lysosome Assembly Pathway
UMLS_CUI	C2984253
KEGG_ID	hsa04142
ALT_DEFINITION	Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.KEGG
FULL_SYN	Lysosome Assembly PathwayPTNCI LysosomePTKEGG
code	C91440
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