About: Leukocyte Transendothelial Migration Pathway

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Leukocyte Transendothelial Migration Pathway Goto Sponge NotDistinct Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Leukocyte Transendothelial Migration Pathway
rdfs:subClassOf	Immune Response Regulation Pathway
Semantic_Type	Functional Concept
Preferred_Name	Leukocyte Transendothelial Migration Pathway
UMLS_CUI	C2984252
KEGG_ID	hsa04670
ALT_DEFINITION	Leukocyte migration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (CAM) and then migrate across the vascular endothelium. A leukocyte adherent to CAMs on the endothelial cells moves forward by leading-edge protrusion and retraction of its tail. In this process, alphaL/beta2 integrin activates through Vav1, RhoA, which subsequently activates the kinase p160ROCK. ROCK activation leads to MLC phosphorylation, resulting in retraction of the actin cytoskeleton. Moreover, leukocytes activate endothelial cell signals that stimulate endothelial cell retraction during localized dissociation of the endothelial cell junctions. ICAM-1-mediated signals activate an endothelial cell calcium flux and PKC, which are required for ICAM-1 dependent leukocyte migration. VCAM-1 is involved in the opening of the "endothelial passage" through which leukocytes can extravasate. In this regard, VCAM-1 ligation induces NADPH oxidase activation and the production of reactive oxygen species (ROS) in a Rac-mediated manner, with subsequent activation of matrix metalloproteinases and loss of VE-cadherin-mediated adhesion.KEGG
FULL_SYN	Leukocyte Transendothelial Migration PathwayPTNCI Leukocyte transendothelial migrationPTKEGG
code	C91439
is someValuesFrom of	nodeID://b641796 nodeID://b643065 nodeID://b643787 nodeID://b653683 nodeID://b653689 nodeID://b674255 nodeID://b675697 nodeID://b677070 nodeID://b681517 nodeID://b682054 nodeID://b682106 nodeID://b683000 nodeID://b688155 nodeID://b688179 nodeID://b688207 nodeID://b688244 nodeID://b688950 nodeID://b688973 nodeID://b689007 nodeID://b690968 nodeID://b690996 nodeID://b691213 nodeID://b692063 nodeID://b692086 nodeID://b693576 nodeID://b697092 nodeID://b699456 nodeID://b699537 nodeID://b699879 nodeID://b699922 nodeID://b700717 nodeID://b700784 nodeID://b701108 nodeID://b701139 nodeID://b701184 nodeID://b701257 nodeID://b701444 nodeID://b702196 nodeID://b702818 nodeID://b702902 nodeID://b703083 nodeID://b705191 nodeID://b705265 nodeID://b706146 nodeID://b707508 nodeID://b709152 nodeID://b717704 nodeID://b719536 nodeID://b722753 nodeID://b722765 nodeID://b724401

Faceted Search & Find service v1.16.116 as of Feb 22 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3239 as of Feb 22 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 82 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software