About: Melanoma TRP2 CTL Epitope Vaccine SCIB1

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Attributes	Values
rdf:type	Class
rdfs:label	Melanoma TRP2 CTL Epitope Vaccine SCIB1
rdfs:subClassOf	Melanoma Vaccine
Semantic_Type	Pharmacologic Substance Immunologic Factor
Preferred_Name	Melanoma TRP2 CTL Epitope Vaccine SCIB1
NCI_META_CUI	CL421601
PDQ_Open_Trial_Search_ID	675320
PDQ_Closed_Trial_Search_ID	675320
FULL_SYN	SCIB1CNNCI Melanoma TRP2 CTL Epitope Vaccine SCIB1PTNCI
DEFINITION	A proprietary DNA-based cancer vaccine that encodes a melanoma antigen tyrosinase-related protein 2 (TRP2) cytotoxic T-lymphocyte (CTL) epitope and a modified monoclonal antibody, a chimera of human IgG1/murine IgG2a with T cell mimotopes expressed within the complementarity-determining regions (CDR) of the antibodies, with potential immunostimulating and antineoplastic activities. Upon intramuscular injection and electroporation, melanoma TRP2 CTL epitope vaccine SCIB1 expresses the modified antibody. Subsequently, the Fc component of the engineered antibody targets and binds to the CD64 receptor on the dendritic cells (DCs); upon processing by DCs, the cellular immune system may be activated to induce helper T-cell and CTL immune responses against tumor cells expressing the TRP2 antigen.NCI
code	C91380

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