About: CENP-E Inhibitor GSK-923295     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • CENP-E Inhibitor GSK-923295
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • CENP-E Inhibitor GSK-923295
NCI_META_CUI
  • CL376164
PDQ_Open_Trial_Search_ID
  • 562003
PDQ_Closed_Trial_Search_ID
  • 562003
FULL_SYN
  • CENP-E Inhibitor GSK-923295PTNCI
  • GSK-923295CNNCI
  • Centromere-Associated Protein E Inhibitor GSK-923295SYNCI
DEFINITION
  • A small-molecule inhibitor of the mitotic kinesin centromere-associated protein E (CENP-E), with potential antineoplastic activity. Upon administration, GSK-923295 binds to and inhibits CENP-E, thereby preventing cell division, inducing cell cycle arrest, and ultimately leading to an inhibition of cell proliferation. CENP-E, a kinetochore-associated mitotic kinesin, plays an essential role in chromosome movement during mitosis and regulates cell-cycle transition from metaphase to anaphase.NCI
code
  • C91080
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