About: Akt Inhibitor GDC-0068     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Akt Inhibitor GDC-0068
rdfs:subClassOf
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Akt Inhibitor GDC-0068
NCI_META_CUI
  • CL416279
PDQ_Open_Trial_Search_ID
  • 669600
PDQ_Closed_Trial_Search_ID
  • 669600
FULL_SYN
  • GDC-0068CNNCI
  • Akt Inhibitor GDC-0068PTNCI
DEFINITION
  • An orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Akt inhibitor GDC-0068 binds to and inhibits the activity of Akt in a non-ATP-competitive manner, which may result in the inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.NCI
code
  • C91072
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