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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Trimethoprim
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Trimethoprim
NSC_Code
  • 106568
UMLS_CUI
  • C0041041
CAS_Registry
  • 738-70-5
FDA_UNII_Code
  • AN164J8Y0X
Contributing_Source
  • FDA
ALT_DEFINITION
  • A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. The interference with folic acid metabolism may cause a depression of hematopoiesis. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM-SULFAMETHOXAZOLE COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.MSH2002_06_01
Chemical_Formula
  • C14H18N4O3
Legacy_Concept_Name
  • Trimethoprim
CHEBI_ID
  • CHEBI:45924
FULL_SYN
  • TRIMETHOPRIMPTFDAAN164J8Y0X
  • TRIMETHOPRIMSYDTPNSC0106568
  • TrimethoprimPTNCI
  • TrimpexSYDTPNSC0106568
  • 2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidineSNNCI
  • TrimpexBRNCI
  • ProloprimSYDTPNSC0106568
  • ProloprimBRNCI
DEFINITION
  • A synthetic derivative of trimethoxybenzyl-pyrimidine with antibacterial and antiprotozoal properties. As a pyrimidine inhibitor of bacterial dihydrofolate reductase, trimethoprim binds tightly to the bacterial enzyme, blocking the production of tetrahydrofolic acid from dihydrofolic acid. The antibacterial activity of this agent is potentiated by sulfonamides. (NCI04)NCI
code
  • C908
sameAs
http://linked.open...y/mesh/hasConcept
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