About: bi-shRNA-Furin/GM-CSF-Expressing Autologous Tumor Cell Vaccine     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • bi-shRNA-Furin/GM-CSF-Expressing Autologous Tumor Cell Vaccine
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
  • Immunologic Factor
Preferred_Name
  • bi-shRNA-Furin/GM-CSF-Expressing Autologous Tumor Cell Vaccine
NCI_META_CUI
  • CL416236
PDQ_Open_Trial_Search_ID
  • 666077
PDQ_Closed_Trial_Search_ID
  • 666077
FULL_SYN
  • bi-shRNA-Furin/GM-CSF-Expressing Autologous Tumor Cell VaccinePTNCI
  • FANG VaccineSYNCI
  • bi-shRNA-Furin and Granulocyte Macrophage Colony Stimulating Factor Augmented Autologous Tumor Cell VaccineSYNCI
DEFINITION
  • Autologous tumor cells transfected with a plasmid expressing recombinant human granulocyte macrophage-colony stimulating factor (rhGM-CSF) and bifunctional short hairpin RNA (bi-shRNA) against furin, with potential immunostimulatory and antineoplastic activities. Upon intradermal vaccination of bi-shRNA-furin/GM-CSF-expressing autologous tumor cell vaccine, expressed GM-CSF protein, a potent stimulator of the immune system, recruits immune effectors to the site of injection and promotes antigen presentation. The furin bifunctional shRNA blocks furin protein production. Decreased levels of furin lead to a reduction in the conversion of transforming growth factor (TGF) beta into TGF beta1 and beta2 protein isoforms. In turn, as part of the negative feedback mechanism, reduced furin protein levels inhibit TGFbeta1 and TGFbeta2 gene expression, thereby further decreasing TGF levels. As TGFs are potent immunosuppressive cytokines, reducing their levels may activate the immune system locally and this may eventually cause a cytotoxic T-lymphocyte (CTL) response against the tumor cells.NCI
code
  • C90552
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