About: DCR Ligand-Bearing Liposome-Encapsulated Melanoma Antigens Vaccine     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • DCR Ligand-Bearing Liposome-Encapsulated Melanoma Antigens Vaccine
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
  • Immunologic Factor
Preferred_Name
  • DCR Ligand-Bearing Liposome-Encapsulated Melanoma Antigens Vaccine
NCI_META_CUI
  • CL416224
PDQ_Open_Trial_Search_ID
  • 665353
PDQ_Closed_Trial_Search_ID
  • 665353
FULL_SYN
  • Dendritic Cell Receptor Ligand-Bearing Liposome-Encapsulated Melanoma Antigens VaccineSYNCI
  • Lipovaxin-MMFBNCI
  • DCR Ligand-Bearing Liposome-Encapsulated Melanoma Antigens VaccinePTNCI
DEFINITION
  • A cancer cell-based vaccine containing liposome encapsulated melanoma antigens and an immunomodulatory factor, attached, via a metal chelator, to a dendritic cell receptor (DCR) ligand-containing a metal-affinity tag, with potential immunomodulating and antineoplastic activity. Upon intravenous administration of DCR ligand-bearing liposome-encapsulated melanoma antigens vaccine, the DCR ligand moiety of this vaccine targets receptors on dendritic cells (DCs), thereby presenting the antigens to DCs which may, in turn, stimulate the DCs and may activate the immune system to mount a cytotoxic T lymphocyte (CTL) response against melanoma cancer cell associated antigens.NCI
code
  • C90543
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