About: Cyclin D Modulator ON 013105     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Cyclin D Modulator ON 013105
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Cyclin D Modulator ON 013105
NCI_META_CUI
  • CL416222
PDQ_Open_Trial_Search_ID
  • 664346
PDQ_Closed_Trial_Search_ID
  • 664346
FULL_SYN
  • Cyclin D Modulator ON 013105PTNCI
  • ON 013105CNNCI
DEFINITION
  • A benzyl styryl sulfone analog, and a disodium phosphate ester prodrug of ON 013100, with potential antineoplastic activity. Upon hydrolysis, cyclin D modulator ON 013105 is converted to ON 013100, which blocks cyclin D mRNA translation and decreases protein expression of cyclin D. This may induce cell cycle arrest and apoptosis in cancer cells overexpressing cyclin D and eventually decrease tumor cell proliferation. This agent may exhibit synergistic antitumor activity in combination with other chemotherapeutic agents. Cyclin D, a member of the cyclin family of cell cycle regulators, plays a key role in cell cycle division and is often overexpressed in a variety of hematologic and solid tumors and is correlated with poor prognosis.NCI
code
  • C90541
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