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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • DM-CHOC-PEN
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • DM-CHOC-PEN
NCI_META_CUI
  • CL416220
PDQ_Open_Trial_Search_ID
  • 664344
PDQ_Closed_Trial_Search_ID
  • 664344
FULL_SYN
  • DM-CHOC-PENPTNCI
  • 4-DemethylcholesteryloxycarbonylpenclomedineSNNCI
DEFINITION
  • A cholesterol carbonate derivative of 4-demethylpenclomedine (DM-PEN) with potential antineoplastic alkylating activity. Upon intravenous administration of 4-demethylcholesteryloxycarbonylpenclomedine, the carbonium moiety binds to and alkylates DNA at the N7 guanine position, thereby causing DNA crosslinks. This prevents DNA replication, inhibits cellular proliferation and triggers apoptosis. In addition, due to its lipophilic cholesteryl moiety this agent is able to cross the blood brain barrier (BBB) and therefore can be given intravenously compared to other alkylating agents that need to be given intra-cranially.NCI
code
  • C90539
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