About: Protein Stabilized Liposomal Docetaxel Nanoparticles

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Attributes	Values
rdf:type	Class
rdfs:label	Protein Stabilized Liposomal Docetaxel Nanoparticles
rdfs:subClassOf	Taxane-Pocket Binding Agent
Semantic_Type	Pharmacologic Substance
Preferred_Name	Protein Stabilized Liposomal Docetaxel Nanoparticles
NCI_META_CUI	CL413616
PDQ_Open_Trial_Search_ID	663670
PDQ_Closed_Trial_Search_ID	663670
FULL_SYN	Protein Stabilized Liposomal Docetaxel NanoparticlesPTNCI ATI-1123CNNCI
DEFINITION	A formulation containing protein-stabilized liposome nanoparticles encapsulating the poorly water-soluble, second-generation taxane analog docetaxel with antineoplastic activity. Docetaxel binds to and stabilizes the beta-tubulin subunit, thereby inhibiting microtubule disassembly which results in cell-cycle arrest at the G2/M phase and cell death. This agent also inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and displays immunomodulatory and pro-inflammatory properties by inducing various mediators of the inflammatory response. Compared to the use of toxic carriers to increase solubilization of docetaxel, protein-stabilized liposomal docetaxel improves drug solubility while avoiding carrier-associated toxicity.NCI
code	C90534

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