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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Triaziquone
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Triaziquone
NSC_Code
  • 29215
UMLS_CUI
  • C0040878
CAS_Registry
  • 68-76-8
FDA_UNII_Code
  • F3D5D9P25I
Contributing_Source
  • FDA
ALT_DEFINITION
  • Alkylating antineoplastic agent used mainly for ovarian tumors. It is toxic to skin, gastrointestinal tract, bone marrow and kidneys.MSH2002_06_01
Chemical_Formula
  • C12H13N3O2
Legacy_Concept_Name
  • Triaziquone
CHEBI_ID
  • CHEBI:27090
FULL_SYN
  • TriaziquoneSYDTPNSC0029215
  • TriaziquonePTNCI
  • TRIAZIQUONEPTFDAF3D5D9P25I
DEFINITION
  • An aziridinylbenzoquinone-based alkylating agent with potential antineoplastic activity. The alkylating group in triaziquone becomes activated upon reduction of quinone to the hydroquinone form. This eventually results in the alkylation and crosslinking of DNA, thereby inhibiting DNA replication followed by an induction of apoptosis. In addition, reactive oxygen species may form during redox cycling which may contribute to this agent's cytotoxic activity.NCI
code
  • C903
sameAs
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