About: 2-(indol-3-ylmethyl)-3,3'-diindolylmethane     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • 2-(indol-3-ylmethyl)-3,3'-diindolylmethane
rdfs:subClassOf
Semantic_Type
  • Organic Chemical
Preferred_Name
  • 2-(indol-3-ylmethyl)-3,3'-diindolylmethane
UMLS_CUI
  • C0908038
FULL_SYN
  • 2-(indol-3-ylmethyl)-3,3'-diindolylmethanePTNCI
DEFINITION
  • NCIThe major and active metabolic product of dietary indole-3-carbinol, present in a wide variety of plant food substances from the Cruciferae family, with cytostatic and antiestrogenic properties. 2-(indol-3-ylmethyl)-3,3'-diindolylmethane is an antagonist of estrogen receptor, and could inhibit the proliferation of both estrogen-dependent and -independent breast cancer cells. In addition, this agent also activates binding of the aryl hydrocarbon (Ah) receptor to its cognate DNA responsive element and expression of the Ah receptor-responsive gene CYP1A1.
code
  • C89855
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