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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Tinidazole
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Tinidazole
UMLS_CUI
  • C0040263
CAS_Registry
  • 19387-91-8
  • 25459-12-5
FDA_UNII_Code
  • 033KF7V46H
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug used to treat protozoal infections, such as amebiasis, giardiasis, and trichomoniasis. It belongs to a family of drugs called antiprotozoal agents. Tinidazole is also being evaluated in the treatment of Helicobacter pylori infections in people with low-grade gastric lymphoma.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 43288
PDQ_Closed_Trial_Search_ID
  • 43288
Chemical_Formula
  • C8H13N3O4S
Legacy_Concept_Name
  • Tinidazole
CHEBI_ID
  • CHEBI:63627
FULL_SYN
  • tinidazolePTNCI-GLOSSCDR0000046153
  • TDZABNCI
  • FasigynBRNCI
  • TINIDAZOLEPTFDA033KF7V46H
  • TindamaxBRNCI
  • SimplotanFBNCI
  • TinidazolePTNCI
DEFINITION
  • A 5-nitroimidazole derivative with antiprotozoal property. Although the mechanism of action has not been fully elucidated, it has been suggested that tinidazole is metabolized and yields nitrite anions and metronidazole. Metronidazole's nitro group in turn is reduced via the parasite ferredoxin, thereby generating a series of free nitro radicals including nitro anions. Toxicity is achieved via depletion of sulfhydryl groups and DNA strand breaks with multiple hits having an additive effect and ultimately leading to cell death.NCI
code
  • C890
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