About: CpG Oligodeoxynucleotide GNKG168     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • CpG Oligodeoxynucleotide GNKG168
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
  • Nucleic Acid, Nucleoside, or Nucleotide
Preferred_Name
  • CpG Oligodeoxynucleotide GNKG168
NCI_META_CUI
  • CL413607
PDQ_Open_Trial_Search_ID
  • 662816
PDQ_Closed_Trial_Search_ID
  • 662816
FULL_SYN
  • CpG ODN GNKG168ABNCI
  • GNKG168CNNCI
  • CpG Oligodeoxynucleotide GNKG168PTNCI
DEFINITION
  • A synthetic, 21-mer, unmethylated CpG motif-based oligodeoxynucleotide (ODN), with immunostimulatory activity. CpG oligodeoxynucleotide GNKG168 binds to and activates Toll-like receptor 9 (TLR9) and is taken up into cells by endocytosis; once internalized, it may activate numerous signaling transduction pathways resulting in the release of multiple cytokines, such as immunoglobulins (Igs), interferons (IFNs), interleukins (ILs) and tumor necrosis factor (TNF). Through activation of TLR9, this ODN can directly stimulate B-lymphocytes, dendritic and natural killer (NK) cells, resulting in an increase in innate immunity and antibody-dependent cellular cytotoxicity (ADCC). In addition, through the release of IL-12 and IFN, this agent may induce a preferential shift to the T-helper 1(Th1) phenotype resulting in enhanced CD8+ T cell-mediated antitumor cytotoxicity.NCI
code
  • C88342
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