About: Topical PVDF/Sirolimus     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Topical PVDF/Sirolimus
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Topical PVDF/Sirolimus
NCI_META_CUI
  • CL413605
PDQ_Open_Trial_Search_ID
  • 662743
PDQ_Closed_Trial_Search_ID
  • 662743
FULL_SYN
  • Topical PVDF/RapamycinSYNCI
  • PVDF/Sirolimus TopicalSYNCI
  • Topical PVDF/SirolimusPTNCI
DEFINITION
  • A topical formulation consisting of a polyvinylidene fluoride (PVDF) polymer resin containing the macrolide sirolimus (rapamycin), produced by the organism Streptomyces hygroscopicus, with immunosuppressive activity. Upon application of topical PVDF/sirolimus, sirolimus migrates from the PVDF polymer resin into the skin. Once inside cells, sirolimus binds to the immunophilin FK binding protein-12 (FKBP-12) and forms a sirolimus:FKBP-12 complex. This complex binds to and inhibits the activity of the serine/threonine kinase mammalian target of rapamycin (mTOR), which may result in the suppression of cytokine-driven T-cell activation and proliferation.NCI
code
  • C88340
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