About: Vascular Disrupting Agent BNC105P     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Vascular Disrupting Agent BNC105P
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Vascular Disrupting Agent BNC105P
NCI_META_CUI
  • CL413603
PDQ_Open_Trial_Search_ID
  • 662727
PDQ_Closed_Trial_Search_ID
  • 662727
FULL_SYN
  • Vascular Disrupting Agent BNC105PPTNCI
  • BNC105PCNNCI
DEFINITION
  • A benzofuran-based vascular disrupting agent (VDA) prodrug with potential anti-vascular and antineoplastic activities. Upon administration vascular disrupting agent BNC105P, the disodium phosphate ester of BNC105, is rapidly converted to BNC105; in activated endothelial cells, BNC105 binds to tubulin and inhibits its polymerization, which may result in a blockage of mitotic spindle formation, cell cycle arrest, and disruption of the tumor vasculature. Hypoxic conditions ensue, depriving tumor cells of nutrients and resulting in tumor cell apoptosis. In addition to its VDA activity, this agent has a direct cytotoxic effect on tumor cells by inhibiting tubulin polymerization. BNC105 is not a substrate for the multidrug-resistance P-glycoprotein (Pgp) transporter.NCI
code
  • C88338
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