About: Allogeneic CMV/AdV-Specific Cytotoxic T Lymphocytes     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Allogeneic CMV/AdV-Specific Cytotoxic T Lymphocytes
rdfs:subClassOf
Semantic_Type
  • Cell
  • Pharmacologic Substance
Preferred_Name
  • Allogeneic CMV/AdV-Specific Cytotoxic T Lymphocytes
NCI_META_CUI
  • CL413565
PDQ_Open_Trial_Search_ID
  • 660070
PDQ_Closed_Trial_Search_ID
  • 660070
FULL_SYN
  • Allogeneic CMV/AdV-Specific Cytotoxic T LymphocytesPTNCI
DEFINITION
  • A population of allogeneic cytotoxic T lymphocytes (CTLs) specifically reactive to cytomegalovirus (CMV) and adenovirus (AdV) with potential antiviral activity. Allogeneic CMV/AdV-specific cytotoxic T lymphocytes are prepared by exposing donor-derived CTLs to a lethally irradiated Epstein-Barr virus-positive lymphoblastoid B cell line (EBV-LCL) that has been transduced with a clinical-grade adenoviral vector (Ad5f35CMVpp65) as a source of CMV and AdV antigens. Infusion of these CTLs into stem cell transplant recipients may prevent CMV and AdV viral disease.NCI
code
  • C88310
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