About: C-VISA BikDD:Liposome     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • C-VISA BikDD:Liposome
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • C-VISA BikDD:Liposome
NCI_META_CUI
  • CL412442
PDQ_Open_Trial_Search_ID
  • 654631
PDQ_Closed_Trial_Search_ID
  • 654631
FULL_SYN
  • C-VISA BikDD Plasmid: DOTAP:Cholesterol Liposome-Based NanoparticleSYNCI
  • C-VISA BikDD:LiposomePTNCI
DEFINITION
  • A formulation composed of DOTAP:cholesterol liposome nanoparticles complexed with the plasmid C-VISA BiKDD, with potential antineoplastic activity. C-VISA BikDD: liposome consists of a pancreatic-cancer-specific expression vector VISA (VP16-GAL4-WPRE integrated systemic amplifier) and a pancreatic-cancer-specific promoter CCKAR (cholecystokinin type A receptor) (CCKAR-VISA or C-VISA) which drives expression of the gene BikDD, a mutant form of the potent proapoptotic gene Bik (Bcl-2 interacting killer). Upon administration and transduction into pancreatic tumor cells, expression of BikDD by C-VISA BikDD:liposome may induce pancreatic tumor cell apoptosis and suppress pancreatic tumor cell proliferation. BikDD binds with greater affinity to anti-apoptotic proteins bcl-2, bcl-xl, bcl-w and Mcl-1 and is more potent than wild-type Bik. DOTAP:cholesterol liposome is composed of cationic lipid dioleoyl-trimethylammonium propane (DOTAP) and cholesterol at molar ratio of 1:1.NCI
code
  • C88264
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