About: Ad5.SSTR/TK.RGD     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Ad5.SSTR/TK.RGD
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Ad5.SSTR/TK.RGD
NCI_META_CUI
  • CL412438
PDQ_Open_Trial_Search_ID
  • 654580
PDQ_Closed_Trial_Search_ID
  • 654580
FULL_SYN
  • Ad5.SSTR/TK.RGDPTNCI
  • RGD-Modified Adenoviral Vector Encoding SSTR/TKSYNCI
DEFINITION
  • An RGD-4C-modified, infectivity-enhanced, bicistronic type 5 adenovirus expressing herpes simplex virus thymidine kinase (HSV-tk) gene, a therapeutic suicide gene, and the somatostatin receptor type 2 (SSTR2) gene with potential antineoplastic activity. Modification with the double cyclic peptide RGD-4C allows the virus to bind to cellular integrins, frequently expressed on the surfaces of ovarian cancer cells, instead of the coxsackie and adenovirus (CAR) receptor, which is often nonfunctional in ovarian cancer cells. Upon intratumoral administration, Ad5.SSTR/TK.RGD transfects tumor cells and expresses the HSV-tk gene. After subsequent administration of a synthetic acyclic guanosine analogue prodrug like ganciclovir (GCV), expressed HSV-tk phosphorylates and activates the prodrug, which may result in inhibition of DNA synthesis and apoptosis in HSV-tk-expressing cancer cells. Additionally, as a bystander effect, adjacent non-transfected cells may be killed by the activated antiviral drug. SSTR2 expression allows imaging of gene transfer into tumor cells using a radiolabeled somatostatin analogue.NCI
code
  • C88261
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